Anne Holston Meininger was born on February 9, 1948 in Dublin, Georgia. She graduated from Wheaton High School, Wheaton, Maryland in 1966, and from Judson College, Marion, Alabama in 1969, with major studies in English and French. She was employed as a computer programmer at the National Bureau of Standards from 1969 to 1979, where she worked in the Applied Mathematics Division, Artificial Intelligence Section from 1969-1973, and in the Office of Technical Publications from 1974-1979. She left NBS in 1979.
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